The Thomas laboratory studies the role of fluid transport phenomena in regulating the dynamics and kinetics of cellular and molecular transport processes. The rationale for this work is that it will provide novel design principles for targeted drug delivery strategies in disease therapy. Specifically, we integrate cellular engineering, biochemistry, biomaterials, and immunology fundamentals to 1) elucidate how physical forces regulate seemingly unrelated aspects of cancer such as metastasis and immune suppression as well as 2) develop novel immunotherapeutic strategies to treat immune-regulated diseases such as cancer using engineered biomaterials.

Engineering Immunotherapy

Immunotherapy is emerging as a powerful alternative for the treatment and management of immune-regulated diseases. Our laboratory works at the intersection of drug delivery and materials engineering to develop next-generation approaches in immunotherapy.

Mechanobiology of Immune-pathophysiology

Forces that arise as a result of fluid flow through tissues in the body play critical roles in regulating a variety of physiological and pathophysiological processes, including innate and adaptive immune response, metastasis and hematopoiesis. We seek to understand how such forces either drive pathogenesis or alleviate disease, and how this insight can be exploited for therapeutic purposes.

PI Contact Information

Susan N. Thomas
Georgia Institute of Technology
315 Ferst Drive NW
IBB Building, Room 2315
Atlanta, GA 30332
Phone: 404.385.1126
Fax: 404.385.1397
Email: susan.thomas@me.gatech.edu

Administrative Assistant: Tiffany Johnson
Phone: 404.894.8411
Fax: 404.385.1397
Email: tiffany.johnson@me.gatech.edu

Lab Contact Information

Thomas Lab
Georgia Institute of Technology
315 Ferst Drive NW
IBB 2229, Wing 2B
Atlanta, GA 30332
Phone: 404.385.6380
Fax: 404.385.1397

Affiliations

  • Georgia Institute of Technology
  • The Goerge W. Woodruff School of Mechanical Engineering
  • The Parkher H. Petit Institute for Bioengineering & Bioscience
  • Emory Winship Cancer Institute
  • Metro Atlanta Chamber of Commerce
  • © 2013 Thomas Lab - Georgia Tech. All rights reserved.
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